发明名称 |
NEW CROSS-LINKED DERIVATIVES OF HYALURONIC ACID |
摘要 |
The present invention describes a new class of cross-linked derivatives of partially N-deacetylated hyaluronic acid or derivatives thereof, comprising at least one repeating unit of formula (I) hereinafter depicted and a process for the preparation of said cross-linked derivatives, comprising a multicomponent condensation reaction involving the carboxy groups and the amino groups originating from a partial N-deacetylation of hyaluronic acid or derivatives, together with an aldeyde and an isocyanide. The derivatives thus obtained can be used, alone or in association with biologically and/or pharmacologically active substances, for the preparation of pharmaceutical compositions, biomaterials, surgical and healthcare articles, slow release systems and for the coating of biomedical objects.
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申请公布号 |
WO0218450(A1) |
申请公布日期 |
2002.03.07 |
申请号 |
WO2001EP10063 |
申请日期 |
2001.08.31 |
申请人 |
FIDIA ADVANCED BIOPOLYMERS S.R.L.;RENIER, DAVIDE;CRESCENZI, VITTORIO;FRANCESCANGELI, ANDREA |
发明人 |
RENIER, DAVIDE;CRESCENZI, VITTORIO;FRANCESCANGELI, ANDREA |
分类号 |
A61K47/30;A61K6/08;A61K8/00;A61K8/64;A61K8/65;A61K8/72;A61K8/73;A61K8/81;A61K8/86;A61K8/96;A61K9/00;A61K38/00;A61K38/43;A61K39/00;A61K45/00;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61K48/00;A61K49/00;A61L24/08;A61L27/00;A61L31/00;A61L31/04;A61P29/00;A61P31/00;A61P35/00;A61P43/00;C08B37/08;(IPC1-7):C08B37/08;A61L27/20;A61K9/16 |
主分类号 |
A61K47/30 |
代理机构 |
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代理人 |
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地址 |
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