| 摘要 |
<p>A process for producing a fumaric acid salt of a compound represented by the general formula (II) (wherein R1 represents hydrogen or lower alkyl; and R2 represents lower alkyl) which comprises converting a compound represented by the formula (I) (where in R1 represents hydrogen or lower alkyl) into a carbamate, removing the carbamate group from this compound, alkylating the 3'-position nitrogen atom of the desosamine of the resultant compound to form the compound represented by the general formula (II), and converting this compound into the target acid salt, characterized in that the compound represented by the general formula (I) is converted into a carbamate in the presence of a cyclic ether or a carboxylic ester. By this process, a high-quality erythromycin derivative can be efficiently produced.</p> |
