NEW SYNTHESIS OF SPLA2 INHIBITORS

摘要

A method of making a compound, comprises deprotecting a compound of formula (I), to form the compound of formula (II); where formula (I) isand, formula (II) isand where Rr is H, R10 or -C(O)R10; R2 is R20 -OR20, -SR20, -NR20R20'or -C(O)R20; R3, R4, R5, R6 and R7 are each individually H, halogen, R, -OR, -SR, -NRR', -C(O)R, -C(O)OR, -S(O)R or -S(O)2R; provided that at least one of R4 and R5 is not H; each R, R10 and R20 is individually alkyl, alkenyl, alkynyl, aryl or heterocyclic radical; each R' and R20' is individually H, alkyl, alkenyl, alkynyl, aryl or heterocyclic radical; and P is a protecting group. The method provides an alternative route to indole-3-glyoxyamide compounds.