Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupt the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.
申请公布号
WO0138360(A3)
申请公布日期
2002.03.07
申请号
WO2000US32326
申请日期
2000.11.22
申请人
CHIRON CORPORATION;COIT, DORIS;MEDINA-SELBY, ANGELICA;SELBY, MARK;HOUGHTON, MICHAEL
发明人
COIT, DORIS;MEDINA-SELBY, ANGELICA;SELBY, MARK;HOUGHTON, MICHAEL