| 摘要 |
<p>Propenohydroxamic acid derivatives represented by the following general formula (1) or salts thereof and drugs containing the same: (1) wherein R1 represents hydrogen, alkyl or halogeno; R2 represents cycloalkyl, aryl, heteroaryl, etc.; R3 represents hydrogen, alkenyl, etc.; R5 represents R?6CO-, R6SO¿2-, R6NHCO- or R6NHCS- (wherein R6 represents alkyl, cycloalkyl, cyclic amino, aryl, heteroaryl, etc.); R7 represents hydrogen or a protective group; and A represents CH, nitrogen or oxidized nitrogen. Because of having an excellent TACE inhibitory activity, the above compounds are useful as drugs for preventing and/or treating diseases such as sepsis, rheumatoid arthritis, arthritis deformans, infectious diseases, autoimmune diseases, malignant neoplasm, collagen disease, ulcerative colitis, MOF, non-insulin-dependent diabetes mellitus, etc.</p> |
