发明名称 |
Fremgangsmåte for fremstilling av citalopram |
摘要 |
A method for the manufacture of citalopram characterized in (i) reaction of 1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-5-halophthalane with an activated magnesium to form the Grignard reagent [3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1-yl]propyl]dimethylamine 5-magnesium halide followed by (ii) reaction of [3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1-yl]propyl)dimethylamine 5-magnesium halide with a compound containing a -CN group bound to a leaving group to form citalopram. |
申请公布号 |
NO20021118(D0) |
申请公布日期 |
2002.03.06 |
申请号 |
NO20020001118 |
申请日期 |
2002.03.06 |
申请人 |
H LUNDBECK A/S |
发明人 |
BOLZONELLA, EVA;CASTELLIN, ANDREA;NICOLE, ANDREA |
分类号 |
C07D;C07D307/87 |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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