发明名称 |
Chimeric mammals with human hematopoietic cells |
摘要 |
There is disclosed a chimeric mammal having a stable bone marrow graft of human hematopoietic cells capable of differentiating into multiple lineages of human mature cells, wherein at least 30% of the hematopoietic cells in the mammal's bone marrow are of human origin. The inventive method comprises sublethally irradiating an immunodeficient mammal, infusing human hematopoietic cells into the mammal and administering an effective amount of human mast cell growth factor (MGF) and a human granulocyte macrophage colony stimulating factor/interleukin-3 fusion protein (GM-CSF/IL-3 FP) to promote engraftment of human cells within the chimeric mammal's bone marrow.
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申请公布号 |
US6353150(B1) |
申请公布日期 |
2002.03.05 |
申请号 |
US19910797493 |
申请日期 |
1991.11.22 |
申请人 |
HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP |
发明人 |
DICK JOHN E.;WILLIAMS DOUGLAS E.;LAPIDOT TSVEE |
分类号 |
A61K39/395;A01K67/027;A61K35/28;C07K16/00;(IPC1-7):A01K67/00;A01K67/033;C12N15/63;C12N15/85 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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