发明名称 |
Localized use of nitric oxide-adducts to prevent internal tissue damage |
摘要 |
A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; can be coated per se on a surface of the medical device; can be directly or indirectly bound to reactive sites on a surface of the medical device; or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue.
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申请公布号 |
US6352709(B1) |
申请公布日期 |
2002.03.05 |
申请号 |
US20000661190 |
申请日期 |
2000.09.13 |
申请人 |
NITROMED, INC. |
发明人 |
STAMLER JONATHAN S.;LOSCALZO JOSEPH;FOLTS JOHN D. |
分类号 |
A61L33/10;A61K31/00;A61K31/04;A61K31/095;A61K31/195;A61K31/21;A61K31/275;A61K31/295;A61K31/35;A61K31/405;A61K31/41;A61K31/415;A61K31/495;A61K31/535;A61K31/54;A61K31/60;A61K31/715;A61K33/00;A61K38/00;A61K38/17;A61K38/38;A61K38/49;A61K38/55;A61K39/395;A61K45/00;A61K45/06;A61K47/48;A61L33/00;A61P7/02;(IPC1-7):A61F2/00;A61L15/00;A61K9/14;A61K9/00 |
主分类号 |
A61L33/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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