Antiviral compounds and methods

摘要

The invention provides a polypeptide derived from the glycoprotein D (gD) of an HSV strain and to compositions including such polypeptides. The invention also provides prophylactic devices coated with such compositions. Using such reagents, the invention provides a method of reducing the probability of HSV or HIV infection of a cell and also reducing the probability of HSV or HIV transmission from an HSV+ or HIV+ individual to an HSV- or HIV- individual during physical contact. Furthermore, the invention provides a method to increase the likelihood that a prophylactic device will resist HSV or HIV infection of an individual.