发明名称 |
Pyrazole compounds, pharmaceutical compositions, and methods for modulating or inhibiting erab or hadh2 activity |
摘要 |
The identification, isolation and modification of human ERAB or HADH2 is described. A crystal structure of ERAB or HADH2 is described which may be used in the discovery, identification and characterization of inhibitors or modulators of ERAB or HADH2. This structure provides a three-dimensional description of binding sites of ERAB or HADH2 for structure-based design of inhibitors or modulators thereof as therapeutic agents, for example in the treatment of Alzheimer's disease). <IMAGE> |
申请公布号 |
AU9685401(A) |
申请公布日期 |
2002.03.04 |
申请号 |
AU20010096854 |
申请日期 |
2001.08.17 |
申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
MELWYN A ABREO;JERRY J. MENG;CHARLES SCOTT AGREE |
分类号 |
G01N33/50;A61K31/395;A61K31/437;A61K31/4545;A61K31/496;A61K31/52;A61K31/522;A61K31/55;A61K45/00;A61P25/28;A61P35/00;A61P43/00;C07D471/04;C07D487/04;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/02;C12N15/09;C12Q1/02;G01N33/15;G06F17/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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