| 摘要 |
There have been needed remedies, preventives and diagnostics for diseases caused by apoptosis regulatory or sugar metabolism regulatory signal errors including malignant tumors such as gastric cancer, ovarian cancer, breast cancer, pancreatic cancer and prostatic cancer, cell death inhibitors in ischemic brain, heart, etc., agents protecting normal cells from cell death in treatments with anticancer agents or radiation, or drugs potentiating the effects of existing remedies. A method of regulating apoptosis which involves the step of regulating the Akt activity in cells, in particular, the step of regulating the step of regulating the binding of Hsp90 to Akt; and a means useful in treating or diagnosing diseases which are caused by apoptosis regulatory or sugar metabolisms regulatory signal errors by using the regulation of apoptosis. |
