Production process of l-phenylalanine derivatives by microorganisms

摘要

A process for producing an L-phenylalanine derivative represented by formula (1): (1) wherein R<1>, R<2>, R<3>, R<4>, and R<5> each independently represents hydrogen, a hydroxy group, an alkyl group, having from 1 to 4 carbon atoms), an alkoxy group having from 1 to 4 carbon atoms), a cyano group, a nitro group, a halogen, NR<6>R<7> (wherein R<6> and R<7> each independently represents hydrogen or an alkyl group having from 1 to 4 carbon atoms, or R<6> and R<7> may form a ring and this ring may contain a hetero atom, by utilizing the activity of a microorganism belonging to any one of the genus Cladosporium, the genus Eurotium, the genus Thanatephorus, the genus Gonatobotryum and the genus Sporobolomyces, an ingredient containing the microorganism or a material treated with the microorganism, in the presence of a cinnamic acid derivative and ammonia and high optical-purity L-phenylalanine derivatives obtained by the process.