发明名称 Tetrahydropyran derivatives as nk-1 receptor antagonists
摘要 The present invention relates to compounds of the formula (I):whereinR1 is fluorine or trifluoromethyl;R2 is fluorine or trifluoromethyl;R3 is methyl or hydroxymethyl;R4 represents a variety of substituents; andn is zero, 1 or 2;and pharmaceutically acceptable salts thereof.The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.
申请公布号 AU7995001(A) 申请公布日期 2002.03.04
申请号 AU20010079950 申请日期 2001.08.17
申请人 MERCK SHARP AND DOHME LIMITED 发明人 JOSE LUIS CASTRO PINEIRO;SIMON NEIL OWEN;EILEEN MARY SEWARD;CHRISTOPHER JOHN SWAIN;BRIAN JOHN WILLIAMS
分类号 A61P25/00;C07D309/10;C07D405/06 主分类号 A61P25/00
代理机构 代理人
主权项
地址