发明名称 Treatment of serotonin related disorders using 2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives
摘要 The compounds of formula I may be used in the treatment of disorders of the serotonin system and conditions such as migraines, headaches, anxiety, depression, memory and learning disorders, neurodegenerative diseases, cancer, cerebral infarct, pain and attention deficit hyperactivity disorder. In formula I: Ar is phenyl, napthyl, benzoxozolonyl, indolyl, indolonyl, benzimidizolyl, quinolyl, furyl, benzofuryl, thienyl, benzothienyl, oxazolyl, benzoxazolyl; Ar1 is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl; A is O, S, SO, SO2, C=O, CHOH or -(CR3R4)-; wherein R3 and R4 is hydrogen, methyl, ethyl or propyl; and n is 0, 1 or 2; wherein Ar and Ar1 may be substituted.
申请公布号 NZ506154(A) 申请公布日期 2002.03.01
申请号 NZ20000506154 申请日期 2000.08.04
申请人 PFIZER PRODUCTS INC 发明人 FLIRI, ANTON FRANZ JOSEF;SANNER, MARK ALLEN;DESAI, KISHOR AMRATLAL
分类号 C07D471/04;A61K31/495;A61K31/4985;A61K31/506;A61P1/04;A61P1/08;A61P9/10;A61P15/00;A61P15/08;A61P25/04;A61P25/06;A61P25/14;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P35/00;A61P43/00;(IPC1-7):A61K31/498;A61K31/501 主分类号 C07D471/04
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