Use of a protein kinase C inhibitor in combination with an anti-neoplastic oncolytic agent or in combination with gamma radiation therapy to treat a neoplastic condition

摘要

The compound of formula (I) (all variables defined below) is useful for treating a neoplastic condition in combination with an anti-neoplastic oncolytic or in combination with gamma radiation. R1 is represented by formula (II), (III) or (IV); R1' is H, alkyl, aminoalkyl, monoalkylaminoalkyl or dialkylaminoalkyl; R2 and R2' are independently H, alkyl, alkoxyalkyl, hydroxyalkyl, alkylthio, S(O)alkyl or CF3; R3 is H or CH3CO-; R4, R4', R5, R5', R6, R6', R7 and R7' are independently H, halogen, alkyl, hydroxy, alkoxy, -COO(alkyl), CF3, nitro, amino, acetylamino, monoalkylamino, dialkylamino, alkylthio or S(O)alkyl; R12 is H, alkyl, haloalkyl, cycloalkyl, acetyl, aryl, -CH(aryl)2, amino, monoalkylamino, dialkylamino, guanidino, -C(=N(alkoxycarbonyl)NH(alkoxycarbonyl), amidino, hydroxy, carboxy, alkoxycarbonyl or heterocyclyl; p and q are independently 1, 2, 3 or 4; s is 0, 1, 2 or 3; t is 1 or 2 and u is 0 or 1.