发明名称 |
COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION |
摘要 |
<p>Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic (3.3.1), (4.3.1) or polycyclic azaamide nucleus. Pharmaceutical compositions containing such compounds help stimulate the outgrowth of neurites in nerve cells and augmenting nerve regeneration. Methods of treating nerve cells with such compositions are useful to promote repair of neuronal damage caused by disease and physical trauma.</p> |
申请公布号 |
SI20638(A) |
申请公布日期 |
2002.02.28 |
申请号 |
SI19990020067 |
申请日期 |
1999.07.15 |
申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
KATOH SUSUMU;KAWAKAMI HIROSHI;TADA HIROKI;LINTON MARIA ANGELICA;KALISH VINCENT;TATLOCK JOHN HOWARD;VILLAFRANCA J. ERNEST |
分类号 |
A61K;A61K31/499;A61K31/4995;A61K31/551;A61P25/00;A61P25/16;A61P25/28;A61P43/00;C07D;C07D221/00;C07D223/00;C07D241/00;C07D243/00;C07D263/00;C07D471/08;C07D471/18;C07D498/18;C07D519/00;(IPC1-7):C07D471/08 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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