| 摘要 |
The present invention relates to compounds of the general formula (I) wherei n a.o. 5 R is hydrogen or halogen; R and R2 or R4 and R4' may be together -CH= CH- CH=CH-, optionally substituted by one or two substituents selected from lowe r alkyl, halogen or lower alkoxy; X is -C(O)N(R8)-, (CH2)pO-, -(CH2)pN(R8)-, - N(R8)C(O)- or -N(R8)-(CH2)p-; wherein R8 is hydrogen or lower alkyl; n is 1 or 2; m is 0, 1, 2, 3, or 4; O is 1 or 2; and p is 1 or 2; and to pharmaceutically acceptable acid addition salts thereof. It has been found that the compounds of the present invention are antagonists of the Neurokini n 1 (NK-1, substance P) receptor, and they are therefore useful in the treatme nt of diseases, related to this receptor.
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