PROGRESSION SUPPRESSED GENE 13 (PSGEN 13) AND USES THEREOF

摘要

The invention provides for isolated nucleic acids encoding Progression Suppressed Gene 13 (PS Gen 13) proteins, vectors comprising said nucleic acids, isolated PSGen 13 proteins, and methods of using such molecules to prevent the growth of cancer cells and/or new blood vessels and accordingly to treat patients suffering from cancer. It is based, at least in part, on the characterization of the complete cDNAs encoding rat and human PSGen 13, and on the discovery that increased levels of PSGen 13 expression can suppress the transformed phenotype and inhibit the activities of promoter elements associated with cancer progression and angiogenesis. In various embodiments, the present invention provides a method for inhibiting growth of a cancer cell which comprises contacting the cancer cell with a nucleic acid encoding a PSGen 13 protein, a PSGen 13 protein or a PSGen 13 activator compound in a sufficient amount so as to inhibit growth of the cancer cell. The invention also provides a method for treating cancer in a subject which comprises contacting a cell of the subject with a nucleic acid encoding a PSGen 13 protein in a sufficient amount so as to cause the cell to express the PSGen 13 protein, thereby treating cancer in the subject.