COPOLIMEROS DE BLOCOS DE OXIDO DE BUTILENO E DE OXIDO DE ETILENO TENSIOACTIVOS COMO REVESTIMENTOS ESTABILIZADORES PARA ORMULACOES DE NANOCRISTAIS

摘要

This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene oxide and butylene oxide and a method of making such nanoparticles. The compositions exhibit reduced macrophage uptake and improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished.