ATTENUATED MICROORGANISM STRAINS EXPRESSING HPV PROTEINS

摘要

This application relates to the use of attenuated prokaryotic microorganism strains (such as Salmonella ) expressing nucleic acid encoding HPV proteins as vaccines against HPV infection and the associated increased risk of cancer. In particular, the work shows that it is possible to assemble VLPs in a prokaryotic organism and that nasal immunization of mice with the strains HPV-specific conformationally dependent and neutralizing antibodies in serum and genital secretions. The experiments described herein show that it is also possible to assemble chimeric VLPs of an HPV including a fusion partner and that tumor protection can be induced.