PLATINUM-MEDIATED SYNTHETIC PROCESS FOR DELTA <4>-1,2,4-OXADIAZOLINES

摘要

DELTA <4>-1,2,4-oxadiazolines, of the general formula (I) (R<1>)=H; R, R<2> or R<3>= alkyl or aryl), are prepared by the [2+3] cycloaddition reaction, in mild conditions, between organonitrile ligands (NCR), activated by coordination to platinum centres, and nitrones ON(R<3>)=C(R<1>)(R<2>), giving complexes with DELTA <4>-1,2,4-oxadiazolines which are liberated from the binding metal centres (in high yields) upon displacement with pyridine or an organophosphine.