THIOETHER-SULPHAMATE STEROIDS AS STEROID SULPHATASE INHIBITORS AND ANTI-CANCER COMPOUNDS

摘要

There is provided a compound of Formula (I) wherein X is a ring having at least 4 atoms in the ring; K is a hydrocarbyl group: R<1> is an optional group of the formula -L<1>-S-R<1'>, wherein L<1> is an optional linker group and R<1'> is a hydrocarbyl group; R<2> is an optional group of the formula -L<2>-S-R<2'>, wherein L<2> is an optional linker group and R<2'> is a hydrocarbyl group; R<3> is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein at least one of R<1> and R<2> is present, and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.