| 发明名称 |
METHOD OF AND APPARATUS FOR OBTAINING UREA WITH GOOD CONVERSION EFFICIENCIES AND LOW ENERGY CONSUMPTION |
| 摘要 |
Compounds of formula (I) and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as stromelysin, gelatinase, matrilysin and collagenase, and are useful in the treatment of mammals having disease-states alleviated by the inhibition of such matrix metalloproteases. |
| 申请公布号 |
PL182639(B1) |
申请公布日期 |
2002.02.28 |
| 申请号 |
PL19950321024 |
申请日期 |
1995.11.21 |
| 申请人 |
SYNTEX /USA/ INC.;AGOURON PHARMACEUTICALS INC. |
发明人 |
CASTELHANO ARLINDO L.;BENDER STEVEN L.;DEAL JUDITH G.;HORNE STEPHEN;LIAK TENG J.;YUAN ZHENGYU |
| 分类号 |
C07D213/82;A61K31/16;A61K31/165;A61K31/195;A61K31/215;A61K31/235;A61K31/27;A61K31/34;A61K31/343;A61K31/38;A61K31/381;A61K31/397;A61K31/403;A61K31/404;A61K31/405;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/66;A61K31/662;A61K38/00;A61P1/02;A61P3/08;A61P3/10;A61P27/02;A61P29/00;A61P35/00;A61P43/00;C07C51/60;C07C53/42;C07C57/72;C07C67/313;C07C67/317;C07C69/353;C07C69/533;C07C231/02;C07C233/47;C07C237/22;C07C237/42;C07C255/57;C07C255/60;C07C259/06;C07C271/20;C07C271/22;C07C279/14;C07C311/46;C07C317/38;C07C317/40;C07C323/52;C07C323/59;C07C323/60;C07C323/63;C07C327/12;C07C327/22;C07C327/30;C07C327/32;C07D205/08;C07D209/20;C07D213/75;C07D213/80;C07D263/22;C07D263/26;C07D295/13;C07D307/91;C07D333/76;C07F9/30;C07F9/32;C07F9/34;C07F9/36;C07F9/48;C07F9/58;C07F9/60;C07F9/62;C07F9/6558;C07K5/023 |
主分类号 |
C07D213/82 |
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