| 摘要 |
6-Substituted 4-(N-(phenyl, benzyl or phenethyl)-N-(tert. butoxycarbonyl)-amino)-quinazoline derivatives (I) are new. Quinazolines of formula (I) and their tautomers, stereoisomers and salts are new. Ra = CH2Ph, CHMePh or Ph'; Ph' = phenyl substituted by R1-R3; R1, R2 = H, F, Cl, Br, Me, CF3, OMe, CN or CCH; R3 = H, F or Cl; Rb = OH, (1-4C) alkylcarbonyloxy, NH2 or NO2; Rc = H, F, Cl, Br, 1-4C alkoxy, 4-6C cycloalkoxy or (3-6C) cycloalkyl-(1-3C) alkoxy; 2-4C alkoxy substituted in the beta --, psi - or delta -position by R4; or 1-(Q)-piperidin-4-yloxy, 1-(Q)-piperidin-4-ylmethoxy, 2-(1-(Q)-piperidin-4-yl)-ethoxy, 3-(1-(Q)-piperidin-4-yl)-propoxy, tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetrahydropyran-4-yloxy, tetrahydrofuran-ylmethoxy or tetrahydropyranylmethoxy; R4 = OQ, NMe2, NEt2, pyrrolidino, piperidino, morpholino or 4-(Q)-piperazino; Q = Me or Et. An Independent claim is included for the preparation of (I).
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