CARBOXYLIC ACID DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

Carboxylic acid derivatives represented by the following general formula (I) and nontoxic salts thereof: (I) wherein R<1> represents COOH, COOR<6>, etc.; A represents alkylene, etc.; R<2> represents alkyl, alkenyl, alkynyl, etc.; B represents a carbon ring or a heterocycle; R<4> represents alkyl, cycloalkyl, etc.; and R<5> represents a carbon ring or a heterocycle. The compounds represented by the general formula (I) bind to PGE2 receptors, in particular, subtypes EP3 and/or EP4 and exert an antagonism, which makes them useful in preventing and/or treating diseases such as pain, allergy, Alzheimer and cancer.