USE OF URSODEOXYCHOLIC ACID FOR POTENTIATION OF THE PHOTOTOXIC EFFECT OF PHOTODYNAMIC THERAPY
摘要
A method of potentiating the phototoxicity of photodynamic therapy by co-administering a photosensitizing agent with a photodynamic potentiator from the group consisting of uridioxicolic acid analogs and conjugates thereof having the phototoxicity potentiating effect and allowing for retention of the co-administered agent and acid in the target tissue. The target tissue is then irradiated. A tool for potentiating apoptosis consists of a photosensitizing agent and a non-toxic photodynamic potentiator. Further, a method of potentiating drug induced apoptosis is provided by administering a photosensitizing agent and then decreasing the threshold of responsiveness of a target tissue to a photokilling effect of the photosensitizing agent.
申请公布号
WO0182860(A3)
申请公布日期
2002.02.28
申请号
WO2001US12813
申请日期
2001.04.20
申请人
WAYNE STATE UNIVERSITY;KESSEL, DAVID;REINERS, JOHN, J.