PDE4 INHIBITOR ISOQUINOLINYLIDENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM

摘要

Compounds of the general formula (I) wherein R<10> means saturated 4 to 7 membered ring containing one or two nitrogen atom(s) connecting through the nitrogen atom and optionally substituted by a C1-4 alkyl group or a satured 4 to 7 membered ring containing one nitrogen atom and one oxygen atom connecting through the nitrogen atom and optionally substituted by a C1-4 alkyl group, X stands for sulfur atom or oxygen atom, are strong and selective inhibitors of PDE4 enzyme and they are presumably suitable for the treatment of for instance asthma, chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis.