发明名称 PHARMACEUTICAL COMPOSITIONS OF PEPTIDES HAVING LOW SOLUBILITY IN PHYSIOLOGICAL MEDIUM
摘要 1. A pharmaceutical composition comprising: a) an LHRH peptide agonist, an LHRH antagonist or a growth hormone releasing factor peptide as active ingredient; b) nicotinamide; and c) a physiological aqueous solution. 2. The pharmaceutical composition according to claim 1, wherein the active ingredient is an LHRH peptide antagonist. 3. The pharmaceutical composition according to claim 1 or claim 2, wherein the active ingredient is Antide or human GRF. 4. The pharmaceutical composition according to any one of claims 1 to 3, which is lyophilised and reconstitutable and further comprises one or more stabilizing agents. 5. The pharmaceutical composition according to any one of claims 1 to .4, which further comprises propylene glycol. 6. The pharmaceutical composition according to any one of claims 1 to 5, which is suitable for parenteral, oral, nasal or pulmonary administration route. 7. The pharmaceutical composition according to any one of claims 1 to 6, further comprising one or more pharmaceutically acceptable excipients. 8. The pharmaceutical composition according to any one of claims 1 to 7, which is suitable for injections. 9. The pharmaceutical composition according to any one of claims 1 to 8, which has the following composition ranges: antide or hGRF 0.1 - 20.0 mg nicotinamide 10 - 300 mg propylene glycol 0 - 800 mg aqueous phase, q.s. 1.0 ml.
申请公布号 EA002227(B1) 申请公布日期 2002.02.28
申请号 EA19990001089 申请日期 1998.05.26
申请人 APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. 发明人 RICHARDSON, PETER
分类号 A61K9/08;A61K9/19;A61K38/00;A61K38/04;A61K38/09;A61K38/25;A61K47/10;A61K47/12;A61K47/18;A61K47/22;A61P5/02;A61P5/10;A61P39/00 主分类号 A61K9/08
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