PROCESS FOR SOLUBILIZING GLUCAGON-LIKE PEPTIDE 1 (GLP-1) COMPOUNDS
摘要
Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
申请公布号
WO0155213(A3)
申请公布日期
2002.02.28
申请号
WO2001US00010
申请日期
2001.01.16
申请人
ELI LILLY AND COMPANY;PROUTY, WALTER, FRANCIS, JUNIOR;RINELLA, JOSEPH, VINCENT, JUNIOR