| 摘要 |
There is provided a method and assay for detecting if a subject, especially subjects over the age of 79, is at increased risk of developing late onset Alzheimer's disease (AD) by directly or indirectly detecting polymorphisms in the cystatin C gene (CST3) in the subject, and observing whether or not the subject is at increased risk of developing late onset AD by determining the alleles present at an AD associated CST3 polymorphism, wherein the presence of particular alleles at the CST3 polymorphism indicates said subject is at increased risk of developing late onset AD. Also provided is a method useful as an aid in determining the prognosis for late onset Alzheimer's Disease (AD) of a subject by detecting the presence or absence of an CST3 GG genotype in the subject, observing that (i) the subject's prognosis is more negative for late onset AD if the presence of the CST3 GG genotype is detected than if it is absent, or that (ii) the subject's prognosis is more positive for late onset AD if the CST3 GG genotype is absent than if it is detected. A method of detecting if a subject is at increased risk of developing late onset Alzheimer's disease by directly or indirectly determining the secreted levels of cystatin C in the subject and/or determining the intracellular levels of cystatin C in the subject.
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