ANTISENSE RNA EXPRESSION STRATEGIES EFFECTIVE AGAINST <i>STREPTOCOCCUS THERMOPHILUS</i> BACTERIOPHAGE
摘要
Recombinant bacteria containing nucleotide sequences encoding <i>Streptococcus thermophilus</i> phage helicase and primase genes expressed in the antisense orientation and methods of making and using the same are disclosed. Replication of bacteriophage infecting this bacterial cell, can be inhibited or decreased by constitutively expressing, the antisense oligonucleotide encoding for <i>S. thermophilus</i> phage helicase or primase.
申请公布号
WO0216550(A2)
申请公布日期
2002.02.28
申请号
WO2001US26033
申请日期
2001.08.20
申请人
NORTH CAROLINA STATE UNIVERSITY;KLAENHAMMER, TODD, R.;STURINO, JOSEPH, MICHAEL