| 摘要 |
1. An intraoral or intranasal transmucosal preparation comprising levosimendan or a pharmaceutically acceptable salt thereof as a therapeutically active ingredient, together with one or more pharmaceutically acceptable excipients. 2. A preparation according to Claim 1, which is a buccal, sublingual or sinuidal transmucosal preparation. 3. A preparation according to Claim 1 or 2, which is in the form of a mucoadhesive preparation. 4. A preparation according to any of Claims 1-3, which comprises mucoadhesive matrix. 5. A preparation according to any of Claims 1-4, which is in the form of a patch. 6. Use of levosimendan or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for transmucosal administration to oral or nasal mucosa of levosimendan or a pharmaceutically acceptable salt thereof. 7. A method for treating heart failure comprising administering transmucosally, particularly to oral or nasal mucosa, a therapeutically effective amount of levosimendan or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 8. A method of administering transmucosally, particularly to oral or nasal mucosa, levosimendan or a pharmaceutically acceptable salt thereof to a patient, wherein the method comprises contacting an intact mucous membrane with a source of levosimendan or a pharmaceutically acceptable salt thereof, and maintaining said source in contact with said mucous membrane for a sufficient time period to deliver said levosimendan or a pharmaceutically acceptable salt thereof to the patient. |
