| 发明名称 |
METHODS OF TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES WITH CPG-CONTAINING POLYNUCLEOTIDE |
| 摘要 |
The present invention relates to DNA vaccines useful for the prevention and treatment of ongoing autoimmune diseases. The compositions and methods of th e invention feature the CpG oligonucleotide, preferably in a motif flanked by two 5' purines and two 3' pyrimidines. The vaccine may further comprise DNA encoding a specific antigen, or the peptide antigen itself. The invention is exemplified for IDDM.
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| 申请公布号 |
CA2420499(A1) |
申请公布日期 |
2002.02.28 |
| 申请号 |
CA20012420499 |
申请日期 |
2001.08.23 |
| 申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
QUINTANA, FRANCISCO J.;COHEN, IRUN R. |
| 分类号 |
C12N15/09;A61K38/17;A61K39/00;A61K39/39;A61K48/00;A61P3/10;A61P37/02;C07K14/47;C12N15/117;(IPC1-7):C12N15/12;A61K38/00;A61K31/708 |
主分类号 |
C12N15/09 |
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