DERIVATIVES OF IMIDAZOLE ELICITING INHIBITORY ACTIVITY WITH RESPECT TO FARNESYLTRANSFERASE, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION

摘要

organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of imidazole of the general formula (I) where n1 means a whole number from 1 to 3; A means hydrogen atom, linear or branched C1-C10-alkyl that can be optionally substituted with C3-C7- cycloalkyl or lower alkoxy-group, or radical taken among the group indicated in the invention claim; Y means radical taken among the group described in the invention claim, or to its novel pharmaceutically acceptable salts. Compounds show inhibitory activity with respect to activity of farnesyltransferase. Also, invention relates to method of synthesis of these compounds, intermediate compounds and pharmaceutical composition based on new derivatives of imidazole. Invention can be used in medicine for prophylaxis and treatment of cancer. EFFECT: new compounds indicated above, improved method of synthesis, valuable antitumor properties. 12 cl, 7 tbl