| 摘要 |
PURPOSE: Provided are a temperature sensitive phosphagen trimer-platinum complex, its producing method and a composition of an anticancer agent containing it as an active ingredient, thereby developing an anticancer agent which has an excellent anticancer activity with less toxicity. CONSTITUTION: The temperature sensitive phosphagen trimer-platinum complex is represented by formula(1), in which m is an integer of 2, 7 and 12; n is an integer of 0, 1, 2 and 3; x is an integer of 0, 1 and 2; A2 is double figures chelate amine selected from 2,2-dimethyl-1,3-propanediamine, 1,2-diaminocyclohexane or 1,1-diaminomthylcyclohexane. The method for producing the temperature sensitive phosphagen trimer-platinum complex comprises the steps of: hydrolyzing the intermediate of cyclic phosphagen trimer represented by the formula(2) with alkali earth metals of formula(3) or alkali metals of formula(4) to produce alkali earth metal salts of formula(5) or alkali metal salts of formula(6); and reacting the cyclic phosphagen trimer-alkali metal salts with (diamine) platinum (II) acidic salts of formula(7) in a ratio of 1:3.
|
