发明名称 |
STABILIZERS FOR LYOPHILIZED VACCINES |
摘要 |
<p>Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.</p> |
申请公布号 |
EP1083883(A4) |
申请公布日期 |
2002.02.27 |
申请号 |
EP19990955214 |
申请日期 |
1999.05.28 |
申请人 |
MERCK &, CO., INC. |
发明人 |
VOLKIN, DAVID, B.;BURKE, CARL, J.;SHEU, SU-PI |
分类号 |
C12N7/00;A61K9/00;A61K9/19;A61K39/00;A61K39/12;A61K39/13;A61K39/165;A61K39/20;A61K39/245;A61K39/25;A61K39/29;A61K39/295;A61K47/00;A61K47/02;A61K47/10;A61K47/12;A61K47/26;A61K47/42;A61P31/12;(IPC1-7):A61K9/19 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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