| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention relates to novel bis(amides) of nitrogen-containing tricyclic carboxylic acids of the formula (I) where each X can be similar or different in this molecule and means - CH= or -N=; each of R1- R4 can be similar or different and means H, C1- C4-alkyl, NH2, C1- C4-alkoxy-group, phenyl, phenoxy-group, NHR, N(R)2,CF3 or halogen atom where R means C1- C4-alkyl; each of R5 and R6 means H or C1- C4- alkyl; Z means ; R7 is H or C1- C4-alkyl; n and m mean the whole number from 1 to 4, or their pharmaceutically acceptable salts with exception of compounds where each X means N, each of R1- R6 means H, carboxamide moiety is bound at position 1 of phenazine ring and Z means or (CH2)3NH(CH2)2NH(CH2)3.. Compounds of the formula (I) show antitumor activity and can be used in medicine. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 7 cl, 1 dwg, 2 tbl, 81 ex
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