发明名称 |
Tolerogenic fragments of natural allergens |
摘要 |
The present invention relates to a process for the controlled enzymatic cleavage of purified and depigmented active allergenic proteins from indoor and outdoor source materials, which process produces fragments of allergens that retain the the natural T-lymphocyte stimulating epitopes, but are depleted of IgE-binding B-cell epitopes and complement-activating agents. The invention also relates to the new pharmaceutical products. These allergen fragments do not exhibit the disadvantages of conventional allergenic extracts for immunotherapy and can be safely used to induce a state of specific T-cell anergy and immunological tolerance in allergic human beings.
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申请公布号 |
US6350590(B1) |
申请公布日期 |
2002.02.26 |
申请号 |
US20000530277 |
申请日期 |
2000.06.23 |
申请人 |
C.B.F. LETI, S.A. |
发明人 |
BERRENS LUBERTUS;GONZALES ROMANO MARIA LETICIA;GALLEGO CAMARA MARIA TERESA |
分类号 |
A61K38/11;A61K39/35;A61K39/36;A61P37/00;A61P37/08;C07K14/435;(IPC1-7):A61K39/35;A61K35/78 |
主分类号 |
A61K38/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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