TREATMENT OF HEPATIC DISEASES USING FK 506 AND RELATED COMPOUNDS

摘要

The disclosure describes the administration of macrolide compounds having the structure: (see formula I) wherein R1 is hydroxy or protected hydroxy, R2 is hydrogen, hydroxy or protected hydroxy, R3 is methyl, ethyl, propyl or a11y1, R4 is hydroxy, methoxy or oxo (=O), n is an integer of 1 or 2 and the symbol of a line and a dotted line is a single bond or a double bond, provided that R2 is not protected hydroxy when R4 is hydroxy or oxo, and salts thereof, for regener- ating mammal liver tissue, stimulating hypertrophy and hyperplasia of hepatocytes and treating hepatic disease.