发明名称 |
Conjugated peptide nucleic acids having enhanced cellular uptake |
摘要 |
Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.
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申请公布号 |
US6350853(B1) |
申请公布日期 |
2002.02.26 |
申请号 |
US19990404430 |
申请日期 |
1999.09.23 |
申请人 |
NIELSEN PETER E. |
发明人 |
NIELSEN PETER E.;KNUDSEN HELLE |
分类号 |
A61K9/127;A61K38/00;A61K47/48;C07H21/00;C07K14/00;C12N15/113;C12Q1/68;(IPC1-7):A61K9/127;A61K31/712;A61K38/02;C07K2/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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