(S)(+)-2-ETHOXY-4-[N-{1-(2-PIPERIDINO-PHENYL)-3-METHYL-1-BUTYL]AMINOCARBONYLMETHYL]BENZOIC ACID

摘要

The present application relates to the new (S) (+)-2- ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]- aminocarbonylmethyl]-benzoic acid and the salts thereof, which have valuable pharmacological properties, namely an effect on the intermediate metabolism, but particularly the effect of lowering blood sugar. The (S)-enantiomer has the general formula: (see formula I) wherein W' represents a carboxy group or an alkoxycarbonyl group having a total of 2 to 5 carbon atoms, wherein the alkyl moiety of the alkoxy group may be substituted by a phenyl group. The invention also relates to the new intermediate products of formulae I, III, IV, and VII and the addition salts thereof. The intermediates are compound of general formulae: (see formula II) (see formulas III,IV, V) A represents a group which can be converted into a carboxy group by hydrolysis, thermolysis or hydrogenolysis, W' represents a carboxy group or an alkoxycarbonyl group having a total of 2 to 5 carbon atoms, wherein the alkyl moiety of the alkoxy group may be substituted by a phenyl group, and W" represents a group which may be converted by oxidation into a carboxy group, and the addition salts thereof. The new compounds can be produced using methods which are known for analogouscompounds.