发明名称 |
Hepatitis B virus (HBV) antigenic polypeptide-heat shock protein complex and use thereof |
摘要 |
The present invention provides a kind of HBV-antigen bound to heat shock proteins(hsps) which comprises core antigen, surface antigen and polymerase antigen. The present invention also provides a complex of HBV antigen bound to heat shock protein gp96 and hsp78, as well as a method for preparing the complex. The complex includes a complex of gp96 and hsp78 non-covalently bound to antigenic polypeptide, as well as a fusion protein of both which results from covalent binding. Such complex can be used to prepare therapeutic vaccine for treating hepatitis B and primary hepatocellular carcinoma. |
申请公布号 |
AU4633101(A) |
申请公布日期 |
2002.02.25 |
申请号 |
AU20010046331 |
申请日期 |
2001.02.27 |
申请人 |
INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES |
发明人 |
BO TIAN;SONGDONG MENG;GRORGE F. GAO |
分类号 |
A61K39/29;A61P1/16;A61P31/20;A61P35/00;C07K14/02;C07K14/47;C07K19/00 |
主分类号 |
A61K39/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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