Oral drug composition containing a verapamil derivative as a drug-absorption promotor

摘要

The bioavailability of a drug which is not readily absorbed in the digestive tract can be greatly enhanced by administering an oral composition comprising a drug and a compound of formula (I): wherein, X is CN, COOH, COOR<10) is C1-2 alkyl), SO2Ph or SPh; k, l, m and n are each independently an integer of 0 to 4; R<1> is H or C1-3 alkyl; and R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> and R<9> are each independently H, OH or C1-3 alkoxy.