Method for the crystallization of iopamidol

摘要

Disclosed is the crystallization of Iopamidol using a mixture of an alcohol and water as a crystallization solvent. The ratios of water:Iopamidol from 1:10 to 1:1 (v/w) and alcohol:Iopamidol from 1:1 to 1:10 (v/w) allow Iopamidol to be crystallized to an anhydrous pure form with industrially valuable yields without producing monohydrates and pentahydrates.