| 摘要 |
<p>The invention relates to a composition comprising an amino acid like structure carrying a sulfur moiety and a biologically acceptable carrier. The amino acid like structure carrying a sulfur moiety may be taurine, L-cysteine, L-methionine, or a combination of these. The composition may be used for inhibition of islet dysfunction or for inhibition of an autoimmune disorder. Conditions of islet dysfunction include insulitis, Type 1 diabetes (IDDM), Type 2 diabetes (NIDDM), mature onset diabetes of the young (MODY), and gestational diabetes. Autoimmune disorders inhibited by the composition include insulinitis, Type 1 diabetes, rheumatoid arthritis, thyroiditis and pancreatitis. The composition may be prepared as a pharmaceutical, a nutraceutical, food supplement, maternal supplement, or infant formula to be administered to individuals having or at risk of developing a condition of islet dysfunction or an autoimmune disorder. The composition can act to inhibit islet dysfunction through exerting anti-apoptotic or immunomodulatory activity. Further, methods are provided for inhibiting islet dysfunction and for inhibiting an autoimmune disorder by administering an amino acid like structure carrying a sulfur moiety to an individual in need thereof.</p> |
