发明名称 |
BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE |
摘要 |
The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a BcL-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.
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申请公布号 |
WO0144282(A3) |
申请公布日期 |
2002.02.21 |
申请号 |
WO2000US33793 |
申请日期 |
2000.12.13 |
申请人 |
THE BURNHAM INSTITUTE;REED, JOHN, C.;GODZIK, ADAM |
发明人 |
REED, JOHN, C.;GODZIK, ADAM |
分类号 |
A01K67/027;A61K31/7088;A61K35/76;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C07K14/47;C07K16/18;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/06;C12N5/10;C12N15/09;C12P21/08;C12Q1/68;G01N33/15;G01N33/50;G01N33/566;G01N33/574;(IPC1-7):C12N15/12;C12N15/11;C12N15/62;A61K38/17;G01N33/68;G01N33/53 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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