| 摘要 |
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protei n (HBc) is disclosed that is engineered for both enhanced stability of self- assembled particles and the display of an immunogenic epitope. The display o f the immunogenic epitope is displayed in the immunogenic loop of HBc, whereas the enhanced stability of self-assembled particles is obtained by the presen ce of at least one heterologous cysteine residue near the carboxy-terminus of t he chimer molecule. Methods of making and using the chimers are also disclosed.
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