发明名称 VERFAHREN ZUR HERSTELLUNG VON VERKALKUNGSBESTÄNDIGEM BIOPROSTHETISCHEM GEWEBE
摘要 A method of treating a collagenous biomaterial, such as porcine aortic valve leaflets or bovine pericardium, by exposing the biomaterial to an alcohol to inhibit in vivo calcification. The biomaterial, preferably glutaraldehyde-pretreated, is subjected to an aqueous solution of 60% to 80% lower aliphatic alcohol, such as ethanol for a period of at least 20 minutes, and preferably, 24 to 72 hours. The biomaterial is rinsed, and then stored in either a glutaraldehyde-free environment or an ethanolic solution of glutaraldehyde. In some embodiments, the treatment solutions include an additional anticalcification agent which may be a soluble salt of a metallic cation, such as Al+3 or Fe+3.
申请公布号 DE69429667(D1) 申请公布日期 2002.02.21
申请号 DE1994629667 申请日期 1994.10.20
申请人 THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ANN ARBOR 发明人 LEVY, J.;HIRSCH, DANIELLE
分类号 A61L2/16;A61L27/00;A61L27/36;A61L27/50;A61L27/54;C14C3/00;C14C3/04 主分类号 A61L2/16
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