发明名称 |
SOLID DISPERSION OF IPRIFLAVONE FOR ORAL ADMINISTRATION AND ITS MANUFACTURING METHODS |
摘要 |
This invention relates to an ipriflavone-containing pharmaceutical agent for oral administration with improved bioavailability, wherein ipriflavone is solid-dispersed in the presence of a water-soluble polymer, an absorption fortifier, and an excipient while the crystal of said pharmaceutical agent is prepared in an amorphous form at the same time so that said ipriflavone can be enclosed in said water soluble polymer, and thus even a little amount as well as lower number of dosage of said ipriflavone pharmaceutical agent can increase the effective blood concentration of said ipriflavone pharmaceutical agent and the solubility for the body fluid in the gastrointestinal tract, thereby remarkably improving the bioavailability of said agent which can much reduce both the uncomfortableness in its usage and the burden that is usually laid on the gastrointestinal tract by a heavy dose and also increase the stability during a long-term storage. |
申请公布号 |
WO0213790(A1) |
申请公布日期 |
2002.02.21 |
申请号 |
WO2001KR00642 |
申请日期 |
2001.04.17 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
LEE, HAI, BANG;KHANG, GIL, SON;JEONG, JE, KYO;KU, JEUNG;CHO, SUN, HANG |
分类号 |
C07D311/76;A61K9/14;A61K31/352;A61K47/28;A61P19/10 |
主分类号 |
C07D311/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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