HEPATITIS B VIRUS (HBV) ANTIGENIC POLYPEPTIDE-HEAT SHOCK PROTEIN COMPLEX AND USE THEREOF
摘要
<p>The present invention provides a kind of HBV-antigen bound to heat shock protein which comprises core antigen, surface antigen and polymerase antigen. The present invention also provides a complex of HBV antigen bound to heat shock protein gp96 and hsp78, as well as a method for preparing the complex. The complex includes a complex of gp96 and hsp78 non-covalently bound to antigenic polypeptide, as well as a fusion protein of the both which results from covalent binding. Such complex can be used to prepare therapeutic vaccine for treating hepatitis B and secondary hepatoma.</p>
申请公布号
WO0214370(A1)
申请公布日期
2002.02.21
申请号
WO2001CN00295
申请日期
2001.02.27
申请人
INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES;TIAN, BO;MENG, SONGDONG;GAO, GRORGE, F.